Hard clam (Meretrix lusoria) were reared for 7 months when both photosynthetic bacteria and heterotrophic bacteria (PSB-HB), photosynthetic bacteria alone (PSB), heterotrophic bacteria alone (HB), and neither photosynthetic bacteria nor heterotrophic bacteria (control) were routinely applied to investigate growth, survival, glycogen content, and body composition of clam. Average final individual weight was 6.17, 6.05, 5.81, and 4.17 g for PSB-, HB-, PSB-HB-, and Control-clam, respectively. There was significant differences in individual weight among the treatments but not in survival rate and condition factor. Clam reared with probiotics, (PSB-HB, PSB, and HB) had higher protein, lipid, and glycogen content than the clam of Control. Glycogen content was 64.92, 63.64, 50.52, and 29.82 mg/100g for HB-, PSB-HB-, PSB-, and Control-clam, respectively. After 4 months’ ammonia-N concentration in water of control-pond was greater than 0.3 ppm, higher than that in ponds of other treatments. Control-clam’s poor growth could be attributed to poor water quality.