Three feeding trials were conducted to evaluate the effects ofbeta-1,3-glucan, VST, from Schizophyllum commune, on survival and resistances tostress, starvation and vibriosis infection of Penaeus monodon postlarvae. Threecontrol diets, two commercial microbound diets (MBA and MBB) and steamed chickenegg (SE), were tested with or without addition of 0.2% VST. Three replicateswere conducted for each diet in 0.5t fiberglass tanks at the stocking density of35,000±700 nauplii for 11 days. The results showed postlarvae fed MBA plus microcoated VST had significantlyhigher (p<0.05) resistance against starvation and Vibrio harveyi than postlarvaefed control diet. When VST mixed with other ingredients during the preparationof MBB or SE diet, postlarvae fed with these diets had significantly higher(p<0.05) survival rate and resistance against low temperature stress thanpostlarvae fed control diets. Thus, addition of VST to the diets for P. monodonlarvae will improve their resistance to extreme condition and increase survival.